Retinoic acid (tous les trans), poudre jaune

Marques : MP Biomedicals
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Synonyme(s): all-trans-Retinoic acid,(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid,ATRA,Vitamin A acid,Tretinoin

0219026905 02190269.5 02190269.6 0219026901
ICNA0219026905EA 1014 EUR
ICNA0219026905 ICNA02190269.5 ICNA02190269.6 ICNA0219026901
Retinoic acid (tous les trans), poudre jaune
Retinoic acid

Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that mediates the functions of vitamin A required for growth and development. It affects gene transcription and modulates a wide variety of biological processes like Cell Proliferation, Differentiation, including Apoptosis. Retinoic Acid mediated gene transcription depends on the rate of transport of Retinoic Acid to target cells and the timing of exposure of Retinoic Acid to RARs (Retinoic Acid Receptors) in the target tissues

Retinoic Acid has been used in various differentiation protocols, including B-cells, T cells and neurons and applied clinically to treat cancer as a form of differentiation-induction therapy.

All -trans -Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyse the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Soluble in methanol, chloroform (40 mg/ml) or acetone (30 mg/ml), slightly soluble in ethanol; Insoluble in water. It is recommended that solutions be made fresh for each use.

Formule: C₂₀H₂₈O₂
Poids moléculaire: 300,44 g/mol
Température de stockage: Congélateur
Numéro MDL: MFCD00001551
Numéro CAS: 302-79-4
EINECS: 206-129-0

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Résultats des tests de spécification

Identity Test Passes
FTIR Conforms to Standard
Melting Point 173 - 183°C
l max (isopropanol + sulphuric acid) 353 ± 3 nm
Loss on Drying ≤0.5%

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